Pharmacokinetics and Dialytic Clearance of Isavuconazole during <i>In Vitro</i> and <i>In Vivo</i> Continuous Renal Replacement Therapy

Abstract

The pharmacokinetics (PK) and dialytic clearance of isavuconazole in vitro and in 7 solid organ transplant patients undergoing continuous renal replacement therapy (CRRT) were evaluated. In vivo, mean (± SD) plasma PK parameters of isavuconazole were: <i>C</i> _max 4.00±1.45 mg/L, <i>C</i> _min 1.76±0.76 mg/L, <i>t</i> _½ 48.36±29.78 h, <i>V_ss</i> 288.78±182.11 L, CL_ss 4.85±3.79 L/h, and AUC 54.01±20.98 mg ⋅ h/L. Transmembrane clearance represented just 0.7% of the total isavuconazole clearance. These data suggest that isavuconazole is not readily removed by CRRT and no dose adjustments are necessary.