Concepedia

Representation of therapy-related myelodysplastic syndrome in clinical trials over the past 20 years

Uma Borate, Brianna Norris, Abby Statler, Rongwei Fu, Taylor Bucy, Mikkael A. Sekeres

Blood Advances · 2019 · 15 citations · 39 references

DOIFull text

Open access

Concepts

Abstract

Key Points Patients with t-MDS are underrepresented in clinical trials when taking into account the prevalence of such patients. Eligibility criteria and sponsorship type may contribute to t-MDS patient exclusion.

References

39

Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia

Hagop M. Kantarjian, Yasuhiro Oki, Guillermo Garcia‐Manero et al. · Blood · 2006 · 687 citations · Full text

Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs

Dana E. Rollison, Nadia Howlader, Martyn T. Smith et al. · Blood · 2008 · 653 citations · Full text

Low-Dose Decitabine Versus Best Supportive Care in Elderly Patients With Intermediate- or High-Risk Myelodysplastic Syndrome (MDS) Ineligible for Intensive Chemotherapy: Final Results of the Randomized Phase III Study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group

Michael Lübbert, Stefan Suciu, Liliana Baila et al. · Journal of Clinical Oncology · 2011 · 546 citations · Full text

Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3

Thomas Fischer, Richard M. Stone, Daniel J. DeAngelo et al. · Journal of Clinical Oncology · 2010 · 501 citations · Full text

A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q

Pierre Fenaux, Aristoteles Giagounidis, Dominik Selleslag et al. · Blood · 2011 · 475 citations · Full text