Reduced matrix metalloproteinase and collagen transcription mediated by the TGF‐β/Smad pathway in passaged normal human dermal fibroblasts

Abstract

Our results suggest that reductions in the expression levels of MMPs and collagen types I and III in aging human dermal fibroblasts reflect reduced expression of TGF-β/Smad and TGF-β receptors, thus compromising the TGF-β receptor-binding capacity of fibroblasts; the NF-κB and Akt-JNK/MAPK signaling pathways may play active roles in this process.