Microfluidics for Biomedical Analysis

TLDR

Microfluidic systems have evolved over the past decade, with integrated chips enabling highly sensitive, high‑throughput, low‑cost analysis. The review surveys recent microfluidic advances for biological and biomedical analysis—including nucleic acid and protein diagnostics—in fundamental biology, clinical practice, food safety, and environmental monitoring, aiming to broaden microfluidics’ future applications. The article discusses current challenges and future developments of microfluidic technologies for clinical applications. Combining microfluidics with nanotechnology, 3D printing, and deep learning offers innovative tools for bioanalyses.

Abstract

Abstract Many new techniques and materials have been applied to microfluidic systems in the past decade, and integrated microfluidic chips have become powerful platforms for realizing highly sensitive, high throughput, and low‐cost analysis. This article reviews the latest advancements of microfluidic platforms for biological and biomedical analysis in the fields of fundamental biology research, clinical application, food safety, and environmental monitoring, with a focus on nucleic acid‐based molecular diagnosis and protein‐based immunodiagnosis. The combination of microfluidics with advanced techniques (e.g., nanotechnology, 3D printing, deep learning) would offer innovative new tools for bioanalyses. The current challenges and the future developments of microfluidic technologies for clinical applications are also discussed. It is anticipated that this review will be beneficial to promoting microfluidics toward a broad range of applications in the future.