Single-cell transcriptional analyses of spasmolytic polypeptide-expressing metaplasia arising from acute drug injury and chronic inflammation in the stomach

Abstract

These data necessitate an expansion of the definition of SPEM to include <i>Tff2+Muc6+</i> cells that do not express mature chief cell transcripts such as <i>Gif</i>. Our data demonstrate that SPEM arises by a highly conserved cellular programme independent of aetiology and develops immunoregulatory capabilities in a setting of chronic inflammation.