Ultrasonic Cavitation Facilitates Rapid Synthesis of Trisubstituted Pyrazole Scaffolds through Michael Addition/Domino Cyclization

Abstract

Abstract A series of aryl/indolyl substituted 4, 5‐dihydro‐1H‐pyrazole derivatives were synthesized via a domino method based on Michael addition mediated cyclization of appropriate chalcones. The chalcones were prepared by Witting reaction in which substituted aromatic aldehydes were treated with stable ylides under eco‐friendly ultrasonic cavitation. The pyrazole scaffolds were obtained in excellent yields within a short span of time.