Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum

Abstract

Sixteen new prenylated flavonoids, sinoflavonoids P-Z (<b>1</b>-<b>11</b>) and sinoflavonoids NA-NE (<b>12</b>-<b>16</b>), were isolated from the fruit of <i>Sinopodophyllum hexandrum</i>, along with eight known analogues (<b>17</b>-<b>24</b>). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, ¹H-NMR, ¹³C-NMR, HSQC, HMBC). The cytotoxic activities of compounds <b>1</b>-<b>18</b>, <b>20</b>, and <b>22</b> were evaluated by MTT assay. Compound <b>6</b> showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC₅₀ values of 6.25 and 3.83 μM, respectively.