Germline <i>BRCA</i> -Associated Endometrial Carcinoma Is a Distinct Clinicopathologic Entity

Abstract

We provide novel evidence in favor of EC being part of the <i>gBRCA</i>-associated HBOC-syndrome. <i>gBRCA</i>-associated ECs are enriched for EC subtypes associated with unfavorable clinical outcome. These findings have profound therapeutic consequences as these patients may benefit from treatment strategies such as PARP inhibitors. In addition, it should influence counseling and surveillance of <i>gBRCA</i> carriers.