CD56−CD16+ NK cells from HIV-infected individuals negatively regulate IFN-γ production by autologous CD8+ T cells

Abstract

The percentage of human CD56^- CD16⁺ NK cells increases during chronic infection with human HIV; however, the biologic role of CD56^- CD16⁺ NK cells in HIV infection is unclear. Our results demonstrate that the percentage of CD56^- CD16⁺ NK cells producing IL-10 and TGF-β was higher than CD56^dim CD16⁺ NK cells. CD56^- CD16⁺ NK cells could inhibit IFN-γ production by autologous CD8⁺ T cells, and this inhibition could be partially reversed by anti-IL-10, anti-TGF-β, or anti-PD-L1 mAbs. CD56^- CD16⁺ NK cells are potential targets for the development of novel immune therapies against HIV infection.