ACS Chemical Biology · 2019 · 40 citations · 26 references
Life SciencesBiochemistryMolecular BiologyEnzymologyMetabolismProtein BiochemistryAmino Acid MetabolismPeptide ChemistryProtein MotifsProtein StructureProtein SynthesisPost-translationally Modified Peptide BiosynthesisPost-translationally Modified Peptide Gene ClustersPost-translationally Modified PeptidesPrecursor Biosynthetic Gene ClustersRadical S-adenosylmethionine EnzymesRibosomally Synthesized Peptide BiosynthesisRibosomally Synthesized Peptide Gene ClustersRibosomally Synthesized Peptides
, which led to modification of all six Cys residues in PapA. These studies provide insights into ranthipeptide biosynthesis and expand our understanding of rSAM enzyme chemistry in natural product biosynthesis.
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