The asymmetric function of Dph1–Dph2 heterodimer in diphthamide biosynthesis

ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.

Brian G. Van Ness, James B. Howard, James W. Bodley · Journal of Biological Chemistry · 1980 · 325 citations · Full text

Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme

Yang Zhang, Xuling Zhu, Andrew T. Torelli et al. · Nature · 2010 · 198 citations · Full text

Biosynthesis, Bioorganic Chemistry, Engineering +11

Dph3 Is an Electron Donor for Dph1-Dph2 in the First Step of Eukaryotic Diphthamide Biosynthesis

Min Dong, Xiaoyang Su, Boris Dzikovski et al. · Journal of the American Chemical Society · 2014 · 73 citations · Full text

Biosynthesis, Protein Assembly, Biochemistry +12

Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis

Min Dong, Venkatesan Kathiresan, Michael K. Fenwick et al. · Science · 2018 · 66 citations · Full text

Radical Sam Enzyme, Biosynthesis, Aldo-keto Reductase +12

The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network

Shanow Uthman, Christian Bär, Viktor Scheidt et al. · PLoS Genetics · 2013 · 61 citations · Full text

Biosynthesis, Engineering, Cellular Enzymology +15