Circulating Dipeptidyl Peptidase 3 is a Myocardial Depressant Factor: Dipeptidyl Peptidase 3 Inhibition Rapidly and Sustainably Improves Haemodynamics

Abstract

Our study demonstrated cDPP3 is a newly discovered myocardial depressant factor, the levels of which at admission are associated with mortality in severe HF patients. Furthermore, inhibition of cDPP3 by Procizumab improved haemodynamics in a mouse model of HF. Our results suggest that DPP3 could be a new biomarker and biotarget for severe HF.