A transition-metal-free & diazo-free styrene cyclopropanation

Abstract

An operationally simple and broadly applicable novel cyclopropanation of styrenes using <i>gem</i>-diiodomethyl carbonyl reagents has been developed. Visible-light triggered the photoinduced generation of iodomethyl carbonyl radicals, able to cyclopropanate a wide array of styrenes with excellent chemoselectivity and functional group tolerance. To highlight the utility of our photocyclopropanation, we demonstrated the late-stage functionalization of biomolecule derivatives.