Synthesis, in-vitro cholinesterase inhibition, in-vivo anticonvulsant activity and in-silico exploration of N-(4-methylpyridin-2-yl)thiophene-2-carboxamide analogs

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Medicine, Neurology, Neuroscience +12

Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products

Yvain Nicolet, Oksana Lockridge, Patrick Masson et al. · Journal of Biological Chemistry · 2003 · 830 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Structure of acetylcholinesterase complexed with E2020 (Aricept®): implications for the design of new anti-Alzheimer drugs

Gitay Kryger, Israel Silman, Joel L. Sussman · Structure · 1999 · 747 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +12

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

Keith Vossel, Alexander J. Beagle, Gil D. Rabinovici et al. · JAMA Neurology · 2013 · 744 citations · Full text

Medicine, Neurology, Neuroscience +16

Crystal structure of a human GABAA receptor

Paul S. Miller, A.R. Aricescu · Nature · 2014 · 710 citations

Life Sciences, Neuroscience, Pharmacology +14