Interleukin 6 Promotes<i>Brucella abortus</i>Clearance by Controlling Bactericidal Activity of Macrophages and CD8⁺T Cell Differentiation

Abstract

To date, the implications of interleukin 6 (IL-6) for immune responses in the context of Brucella infection are still unknown. In the present study, we found that Brucella abortus infection induced marked production of IL-6 in mice that was important for sufficient differentiation of CD8 + T cells, a key factor in Brucella clearance.