Publication | Open Access
Total Synthesis and Structural Validation of Phosdiecin A via Asymmetric Alcohol-Mediated Carbonyl Reductive Coupling
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Citations
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References
2019
Year
Asymmetric CatalysisCross-coupling ReactionBiosynthesisEngineeringBiochemistryNatural SciencesTotal SynthesisOrganic ChemistryNatural Product BiosynthesisFostriecin Family MembersChemistryNatural Product SynthesisStructural ValidationSynthetic ChemistryBiomolecular EngineeringPhosdiecin A
The first total synthesis and structural validation of phosdiecin A was accomplished in 13 steps through asymmetric iridium-catalyzed alcohol-mediated carbonyl reductive coupling. The present route is the shortest among >30 total and formal syntheses of fostriecin family members.
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