Chromosomal Abnormalities and Prognosis in <i>NPM1</i>-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts

Abstract

Karyotype abnormalities are significantly associated with outcome in <i>NPM1</i>^mut/<i>FLT3</i>-ITD^neg/low AML. When adverse-risk cytogenetics are present, patients with <i>NPM1</i>^mut share the same unfavorable prognosis as patients with <i>NPM1</i> wild type and should be classified and treated accordingly. Thus, cytogenetic risk predominates over molecular risk in <i>NPM1</i>^mut/<i>FLT3</i>-ITD^neg/low AML.