<i>Spiroplasma eriocheiris</i> Enters <i>Drosophila</i> Schneider 2 Cells and Relies on Clathrin-Mediated Endocytosis and Macropinocytosis

Abstract

Spiroplasma eriocheiris causes great economic losses in the crustacean aquaculture industry. However, the mechanism of S. eriocheiris infecting host cells has been poorly studied. We established a Spiroplasma -infected Drosophila Schneider 2 (S2) cell model and investigated its pathogenic mechanism. First, S. eriocheiris induced S2 cell apoptosis and necrosis, seriously decreased cell viability, and increased the production of intracellular reactive oxygen species.