Concepedia

Cullin7 enhances resistance to trastuzumab therapy in Her2 positive breast cancer via degrading IRS-1 and downregulating IGFBP-3 to activate the PI3K/AKT pathway

Ni Qiu, Yufang He, Siming Zhang, Yongtao Zhan, Guodong Han, Ming Jiang, Weixing He, Jie Zhou, Hongling Liang, Xiang Ao,

Cancer Letters · 2019 · 35 citations · 23 references

DOI

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23

Trastuzumab: Updated Mechanisms of Action and Resistance in Breast Cancer

Thuy Vu, François X. Claret · Frontiers in Oncology · 2012 · 602 citations · Full text

Heterotrimerization of the Growth Factor Receptors erbB2, erbB3, and Insulin-like Growth Factor-I Receptor in Breast Cancer Cells Resistant to Herceptin

Xiaoping Huang, Li‐Zhi Gao, Shuiliang Wang et al. · Cancer Research · 2010 · 245 citations

The CUL7 E3 Ubiquitin Ligase Targets Insulin Receptor Substrate 1 for Ubiquitin-Dependent Degradation

Xinsong Xu, Antonio Sarikas, Dora Dias‐Santagata et al. · Molecular Cell · 2008 · 216 citations · Full text

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CUL7: A DOC domain-containing cullin selectively binds Skp1⋅Fbx29 to form an SCF-like complex

Dora Campos Dias, Georgia Dolios, Rong Wang et al. · Proceedings of the National Academy of Sciences · 2002 · 171 citations · Full text

Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer

Gabriel L. Fiszman, María A. Jasnis · International Journal of Breast Cancer · 2011 · 115 citations · Full text

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