Concepedia

Design, synthesis, and biological evaluation of 4-((6,7-dimethoxyquinoline-4-yl)oxy)aniline derivatives as FLT3 inhibitors for the treatment of acute myeloid leukemia

Qiaoling Xu, Baozhu Dai, Zhiwei Li, Le Xu, Di Yang, Ping Gong, Yunlei Hou, Yajing Liu

Bioorganic & Medicinal Chemistry Letters · 2019 · 17 citations · 35 references

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35

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

Antoine Daina, Olivier Michielin, Vincent Zoete · Scientific Reports · 2017 · 17.1K citations · Full text

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Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

Nicholas A. Meanwell · Journal of Medicinal Chemistry · 2011 · 2.8K citations · Full text

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One-pot synthesis of trifluoroacetimidoyl halides

Kenji Tamura, Hiromichi Mizukami, Kazuhiro Maeda et al. · The Journal of Organic Chemistry · 1993 · 278 citations

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Synthesis, anticancer activity and mechanism of action of new thiazole derivatives

Temístocles Ítalo de Santana, Míria de Oliveira Barbosa, Paulo André Teixeira de Moraes Gomes et al. · European Journal of Medicinal Chemistry · 2017 · 212 citations

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Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 “Gatekeeper” F691L Mutation with PLX3397

Catherine C. Smith, Chao Zhang, Kimberly C. Lin et al. · Cancer Discovery · 2015 · 203 citations · Full text

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