An iterative sparse deconvolution method for simultaneous multicolor ¹⁹F‐MRI of multiple contrast agents

Abstract

The method requires minimal sequence adaptation and is therefore easily implemented on different MRI systems. Simulations, phantom experiments, and in-vivo measurements in mice showed effective separation and removal of chemical shift artifacts below noise level. We foresee applicability for simultaneous in-vivo imaging of ¹⁹ F-containing fluorine probes or for detection of ¹⁹ F-labeled cell populations.