Direct C3 Alkoxylation of Quinoxalin-2(1<i>H</i>)-ones with Alcohols via Cross-Dehydrogenative Coupling under Catalyst-Free Conditions

Abstract

A facile and effective alkoxylation protocol of quinoxalin-2(1<i>H</i>)-ones with primary or secondary alcohols via cross-dehydrogenative coupling under catalyst-free conditions has been disclosed. This method provides a powerful and convenient access to 3-alkoxylquinoxalin-2(1<i>H</i>)-ones in good to excellent yields by utilizing PhI(OTFA)₂ as an oxidant and allows to easily obtain potential drug molecules containing 3-alkoxylquinoxalin-2(1<i>H</i>)-one skeletons.