Synthesis and Antibacterial Evaluation of New Pyrimidyl N‐Ciprofloxacin Derivatives

Abstract

Abstract Herein, nucleophilic substitution reaction of pyrimidine derivatives on piperazine in ciprofloxacin resulted in the formation of new pyrimidyl N‐ciprofloxacines. These compounds were prepared at room temperature, at conventional heating and under microwave irradiation conditions. Results indicated microwave condition as a green approach in comparison with room temperature and at conventional heating condition leads to higher yields and very short reaction times. 1 H, 13 C‐NMR, FT‐IR, Mass spectroscopy and CHN analysis were used to characterize all the synthesized products. Meanwhile, the antibacterial activity of these new compounds against gram‐positive and gram‐negative bacteria was investigated and showed more activities for two new N‐ciprofloxacin derivatives than ciprofloxacin.