Catalytic Transfer Hydrodebenzylation with Low Palladium Loading

Abstract

Abstract A highly‐efficient catalytic system for hydrodebenzylation reaction is described. The cleavage of O ‐benzyl and N ‐benzyl protecting groups was performed using an uncommonly low palladium loading (0.02–0.3 mol%; TON up to 5000) in a relatively short reaction time. The approach was used for a variety of substrates including pharmaceutically important precursors, and gram‐scale deprotection reaction was shown. Transfer conditions together with easy‐to‐make Pd/C catalyst are the key features of this debenzylation scheme. magnified image