Aureonitols A and B, Two New C₁₃‐Polyketides from <i>Chaetomium globosum</i>, an Endophytic Fungus in <i>Salvia miltiorrhiza</i>

Abstract

Two new C₁₃ -polyketides, aureonitols A and B (1 and 2), along with five known compounds (3-7), were isolated from the solid fermentation culture of the plant endophytic fungus Chaetomium globosum from the aerial parts of Salvia miltiorrhiza. The structures and absolute configurations of 1 and 2 were determined by comprehensive spectroscopic data analysis and computed methods. Compound 5 was found to display the remarkable antimicrobial activities against four multidrug-resistant bacteria (Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, and Staphylococcus epidermidis) with MIC values of 3.13-6.25 μg/mL (ciprofloxacin: 0.78-1.56 μg/mL), and also against all tested fungal strains with MIC values of 3.13-25 μg/mL (ketoconazole: 0.78-12.50 μg/mL).