Publication | Closed Access
Synthesis and biological evaluation of thiolate gold(<scp>i</scp>) complexes as thioredoxin reductase (TrxR) and glutathione reductase (GR) inhibitors
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Citations
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References
2019
Year
Inorganic ChemistryMedicinal ChemistryAldo-keto ReductaseBiochemistryMedicineConsiderable Cytotoxic ActivitiesNatural SciencesCoordination ComplexThiolate GoldMolecular ComplexThioredoxin ReductasePharmacologyBiological Inorganic ChemistryRedox BiologyInorganic SynthesisGlutathione ReductaseDrug DiscoveryInorganic Compound
Au(<sc>i</sc>) complexes with PPh<sub>2</sub>py and thiolate ligands are prepared. The complexes are shown considerable cytotoxic activities and those efficiently inhibit the TrxRs and GR.
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