Control of Thyroglobulin Synthesis and Secretion

Abstract

(First of Two Parts) THE thyroid has two main endocrine functions: secretion of the thyroid hormones thyroxine (T4) and triiodothyronine (T3) by the follicular cells and secretion of calcitonin by the C cells. Thyroid hormones are first synthesized as a prohormone, thyroglobulin, which is a large glycoprotein. This prohormone is also released by the thyroid and constitutes a normal plasma component. This article reviews recent developments in the synthesis, secretion and control of thyroglobulin. Wherever possible, we discuss data on the human thyroid gland and the clinical aspects of thyroglobulin secretion. Physiologic Features or the Thyroid. © 1979, Massachusetts Medical Society. All rights reserved.