Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3<i>β</i> Signaling

Abstract

The present study suggests that Nrf2-HO-1 signaling has an inhibitory role in the regulation of EMT through the modulation of ROS-mediated PI3K/Akt/GSK-3<i>β</i> activity, highlighting Nrf2-HO-1 and GSK-3<i>β</i> as potential therapeutic targets in diabetic nephropathy.