Concepedia

Publication | Closed Access

Associations of Th2, Th17, Treg cells, and IgA<sup>+</sup> memory B cells with atopic disease in children: The Generation R Study

DOI

51

Citations

37

References

2019

Year

Kirsten I. M. Looman, Evelien R. van Meel, Christina Großerichter-Wagener, Floor J. M. Vissers, Janice H. Klingenberg, Nicolette W. de Jong, Johan C. de Jongste, Suzanne G.M.A. Pasmans, Liesbeth Duijts, Menno C. van Zelm,
Allergy

Abstract

Children with any atopic disease and children with inhalant- and food-allergic sensitization or atopic dermatitis had higher circulating memory Treg cells, but not higher IgE<sup>+</sup> B-cell numbers. The associations of higher Treg and CD27<sup>+</sup> IgA<sup>+</sup> B-cell numbers in children with food-allergic sensitization are suggestive of TGF-β-mediated compensation for chronic inflammation.

References

YearCitations

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