Is Fe-catalyzed <i>ortho</i> C–H Arylation of Benzamides Sensitive to Steric Hindrance and Directing Group?

Abstract

The previously reported Fe-catalyzed ortho C–H arylation of benzamides relied on bi- or tridentate amide groups and specific iron ligands and was sensitive to steric hindrance. By using new mixed titanates, our present protocol accommodates various weakly coordinating benzamides and tolerates high steric hindrance and sensitive functional groups only under the catalysis of FeCl3 and TMEDA. A wide range of privileged condensed ring compounds can thus be facilely accessed.