Publication | Open Access
Tissue Engineering: 3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts (Adv. Sci. 11/2019)
23
Citations
0
References
2019
Year
Tissue EngineeringEngineeringBiomaterials DesignBiofabricationBiomedical EngineeringRegenerative MedicineCardiovascular Reparative MedicineMatrix BiologyArticle Number 1900344Personalized ThickCardiovascular EngineeringBioprintingPerfusable Cardiac PatchesFunctional Tissue EngineeringTal DvirCell Biology3D BioprintingOmental Tissue3D PrintingTissue RegenerationInduced Pluripotent Stem CellStem-cell TherapyMedicineBiomaterialsHuman TissueExtracellular Matrix
In article number 1900344, Tal Dvir and co-workers take a biopsy of an omental tissue from patients. While the cells are reprogrammed to induced pluripotent stem cells and differentiate into cardiomyocytes and endothelial cells, the remaining extracellular matrix is processed into a thermoresponsive hydrogel. These personalized materials and cells are used as bioinks to print functional vascularized cardiac patches and small-scale human hearts.