Facile Synthesis of 3‐Hydroxy Oxindole by a Decarboxylative Aldol Reaction of β‐Ketoacid and Isatin in WERSA

Abstract

Abstract Facile synthesis of bioactive 3‐hydroxy‐oxindole by decarboxylative aldol reaction via in‐situ generated methyl enolate of β‐ketoacid and isatin in Water Extract of Rice Straw Ash (WERSA) is described. This method provides clean, simple and useful alternative to synthesize 3‐hydroxy‐oxindole. The products were isolated in excellent yield without using column chromatography. The green chemistry matrices calculated, and it also shows green protocol used.