Concepedia

Discovery of δ-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies

Yingying Xu, Ziwen Zhang, Xia Jiang, Xing Chen, Zhuo Wang, Hamed Alsulami, Hua‐Li Qin, Wenjian Tang

European Journal of Medicinal Chemistry · 2019 · 44 citations · 39 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructure-activity RelationshipsAlzheimer DiseaseDementia PharmacotherapyLead Compound DesignLigand-based DesignNeurodegenerative Disease PharmacologyNeurodegenerative Disease PharmacotherapyDementia Drug DevelopmentMedicinal Chemistry ApplicationsMedicinal HeterocyclesPharmacological Treatment Of DementiaPyrazole ChemistryPyrazole SynthesisStructure-based Lead Discovery

References

39

2016 Alzheimer's disease facts and figures

Alzheimer s & Dementia · 2016 · 5.1K citations

Medicine, Geriatric Medicine, Population Health Sciences +17

2018 Alzheimer's disease facts and figures

Alzheimer s & Dementia · 2018 · 1.9K citations

Medicine, Geriatric Medicine, Neurology +17

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

Jiajia Dong, Larissa B. Krasnova, M. G. Finn et al. · Angewandte Chemie International Edition · 2014 · 1.4K citations

Natural Sciences, Chemistry, Green Chemistry +7

Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products

Yvain Nicolet, Oksana Lockridge, Patrick Masson et al. · Journal of Biological Chemistry · 2003 · 830 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

Nigel H. Greig, Tadanobu Utsuki, Donald K. Ingram et al. · Proceedings of the National Academy of Sciences · 2005 · 723 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17