Structural Characterization of a Gold/Serum Albumin Complex

Abstract

The medicinal gold(III) dithiocarbamato complex AuL₁₂ forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin.