Intratumoral <i>Fusobacterium Nucleatum</i> Levels Predict Therapeutic Response to Neoadjuvant Chemotherapy in Esophageal Squamous Cell Carcinoma

Abstract

We conclude that high levels of intratumoral <i>F. nucleatum</i> have a prognostic significance for predicting poor RFS in patients with ESCC. More importantly, our data indicates that higher <i>F. nucleatum</i> burden correlates with poor response to neoadjuvant chemotherapy, suggesting the possibility that an antibiotic intervention against this bacterium may significantly improve therapeutic response in patients with ESCC.