Nature Communications · 2019 · 167 citations · 48 references
Life SciencesNeurologyNeuroscienceCognitive NeuroscienceMemoryNeural CircuitryAlzheimer DiseaseCognitive ImpairmentConnectomicsMemory DisordersMemory SystemsNeural Basis Of MemoryBrain Circuit ArchitectureBrain RegionsEpisodic Memory ImpairmentLesion-connectivity RelationshipsMemory MechanismsMemory ScoresNeural Circuit MechanismsNeural Correlates Of Memory
Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of the human connectome (n = 1000). This circuit is reproducible across discovery (n = 27) and replication (n = 26) cohorts and specific to lesions causing amnesia. Its hub is at the junction of the presubiculum and retrosplenial cortex. Connectivity with this single location defines a human brain circuit that incorporates > 95% of lesions causing amnesia. Lesion intersection with this circuit predicts memory scores in two independent datasets (N1 = 97, N2 = 176). This network aligns with neuroimaging correlates of episodic memory, abnormalities in Alzheimer's disease, and brain stimulation sites reported to enhance memory in humans.
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A default mode of brain function
Marcus E. Raichle, Ann Mary MacLeod, Abraham Z. Snyder et al. · Proceedings of the National Academy of Sciences · 2001 · 12.4K citations