Lurasidone inhibits <scp>NMDA</scp> receptor antagonist‐induced functional abnormality of thalamocortical glutamatergic transmission via <scp>5‐HT₇</scp> receptor blockade

Abstract

The present results indicate that MK-801-induced insular l-glutamate release is generated by activation of thalamo-insular glutamatergic transmission via MDTN GABAergic disinhibition resulting from NMDA receptor inhibition in the MDTN and RTN. Lurasidone inhibited this MK-801-evoked insular l-glutamate release through inhibition of excitatory 5-HT₇ receptor in the MDTN. These effects on thalamo-insular glutamatergic transmission may contribute to the antipsychotic and mood-stabilizing actions of lurasidone.