Photoredox-catalyzed stereoselective alkylation of enamides with <i>N</i>-hydroxyphthalimide esters <i>via</i> decarboxylative cross-coupling reactions

Abstract

Stereoselective β-C(sp²)-H alkylation of enamides with redox-active <i>N</i>-hydroxyphthalimide esters <i>via</i> a photoredox-catalyzed decarboxylative cross-coupling reaction is demonstrated. This methodology features operational simplicity, broad substrate scopes, and excellent stereoselectivities and functional group tolerance, affording a diverse array of geometrically defined and synthetically valuable enamides bearing primary, secondary or tertiary alkyl groups in satisfactory yields.