Dysregulation of N6‑methyladenosine regulators predicts poor patient survival in mantle cell lymphoma

Abstract

N⁶-methyladenosine (m⁶A) is the most abundant eukaryote mRNA modification, modulated by regulators known as epigenetic writers, erasers and readers, which are known to serve crucial roles in mRNA metabolism. However, the role of m⁶A during B-cell development and B-cell tumorigenesis remains poorly understood. By analyzing the gene expression profile of 123 mantle cell lymphoma cases from the Gene Expression Omnibus database, the present study demonstrated that one-half of the m⁶A regulators were able to predict patient survival in mantle cell lymphoma, notably the m⁶A.index. The expression levels of the m⁶A regulators were regarded as good classifiers in mantle cell lymphoma. The m⁶A.index-low mantle cell lymphoma type exhibited a poor patient survival and lower mRNA levels from the total transcriptome. The m⁶A regulators may be associated with the cell division and the RNA metabolic pathways, which may result in poor survival of patients with mantle cell lymphoma.