Targeted Therapy for Severe Asthma in Children and Adolescents: Current and Future Perspectives

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Kian Fan Chung, Sally E. Wenzel, Jan Brożek et al. · European Respiratory Journal · 2013 · 3.9K citations · Full text

Medicine, Internal Medicine, Pediatrics +13

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

Héctor Ortega, Mark C. Liu, Ian Pavord et al. · New England Journal of Medicine · 2014 · 2.3K citations · Full text

Pharmacy, Internal Medicine, Pharmacotherapy +16

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

Ian Pavord, Stephanie Korn, Peter Howarth et al. · The Lancet · 2012 · 2.2K citations

Life Sciences, Internal Medicine, Pharmacotherapy +14

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

Elisabeth H. Bel, Sally E. Wenzel, Philip J. Thompson et al. · New England Journal of Medicine · 2014 · 1.6K citations

Pharmacy, Pharmacology, Pharmacotherapy +17

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

Eugene R. Bleecker, J. Mark FitzGerald, Pascal Chanez et al. · The Lancet · 2016 · 1.4K citations

Pharmacy, Pharmacology, Pharmacotherapy +13