Antimicrobial Agents and Chemotherapy · 2019 · 38 citations · 28 references
Life SciencesInfectious DiseasesMicrobiologyBacteriologyMedical MicrobiologyMicrobial PathogenesisAntibiotic ResistanceAntimicrobial Susceptibility TestingAntimicrobial TherapyBacterial InfectionsBacterial PathogenesisInfective EndocarditisBroth MicrodilutionCoagulase-negative StaphylococciInfectious EndocarditisInfective Endocarditis ProphylaxisMicrobiologic DiagnosisStreptococcal EndocarditisStreptococcus Species
Exebacase, a recombinantly produced lysin (cell wall hydrolase), and comparator antibiotics were tested by the broth microdilution method against strain sets of Staphylococcus and Streptococcus spp., which are the most common causes of infective endocarditis in humans. Exebacase was active against all Staphylococcus spp. tested, including S. aureus and coagulase-negative staphylococci (MIC 50/90 , 0.5/1 μg/ml). Activity against Streptococcus spp.
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Catherine Liu, Arnold S. Bayer, Sara E. Cosgrove et al. · Clinical Infectious Diseases · 2011 · 4.2K citations · Full text