Cascade Reaction for the Synthesis of Carbolines from <i>O</i>‐Methylketoximes and Styrenes via Palladium‐Catalyzed C–H Activation and Sequential Annulation

Abstract

A novel cascade reaction has been described for the synthesis of Carbolines via palladium‐catalyzed successive C–C/C–N formation from O ‐methylketoximes and styrenes. The oxime ether auxiliary not only serves as a traceless directing group, but is also partly transformed into the value‐added pharmacophore in a two‐step, one‐pot fashion.