Diversification of Peptidomimetics and Oligopeptides through Microwave‐Assisted Rhodium(III)‐Catalyzed Intramolecular Annulation

Abstract

Abstract A chemoselective rhodium(III)‐catalyzed cascade annulation for the construction of the indolizinone and quinolizinone scaffolds is developed. Diversification of peptidomimetics and oligopeptides is achieved in a rapid and step‐economical manner through the combination of Ugi reaction and microwave‐assisted rhodium(III)‐catalyzed intramolecular annulation via C( sp 2 )‐H activation without installing a directing group. magnified image