SIAM Journal on Applied Mathematics · 2018 · 22 citations · 33 references
EngineeringMathematicsChemical KineticsDynamical SystemsStochastic ProcessesMarkov ChainsMarkov ProcessesNetwork ModelingNetwork TheoryStochastic NetworksStochastic Systems ModelingChemical Reaction NetworksDeterministic ModelsDiscrete-time State-space ModelsPositive RecurrenceReaction Network ModelingRecurrenceState-space StructureTier Structure Design
We consider discrete-space continuous-time Markov models of reaction networks and provide sufficient conditions for the following stability condition to hold: each state in a closed, irreducible component of the state space is positive recurrent; moreover the time required for a trajectory to enter such a component has finite expectation. The provided analytical results depend solely on the underlying structure of the reaction network and not on the specific choice of model parameters. Our main results apply to binary systems, and our main analytical tool is the “tier structure” previously utilized successfully in the study of deterministic models of reaction networks.
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Stochastic Gene Expression in a Single Cell
Michael B. Elowitz, Arnold J. Levine, Eric D. Siggia et al. · Science · 2002 · 5.7K citations