Journal of Pediatric Intensive Care · 2019 · 19 citations · 18 references
PharmacyPharmacologyPharmacotherapyClinical PharmacologyPediatric Clinical PharmacologyPediatric PharmacotherapyDrug Overdose ManagementLipid Emulsion TherapyLocal Anesthetic ToxicityPediatric Adverse Drug ReactionsPediatric PharmacologyPediatric Poisoning ManagementClonic SeizuresDrug Overdose In ChildrenIntravenous Lipid EmulsionLactic AcidosisLocal Anesthetic AdministrationPediatric Lipid Emulsion TherapyPediatric Overdose ManagementSeizures
Bupropion overdose in the pediatric setting poses significant potential for toxicity. We present the case of a 15-year-old female patient presenting with intentional bupropion overdose resulting in generalized tonic-clonic seizures, severe acidosis, vomiting, and tachycardia after ingestion of between 1,650 to 9,000 mg (24-133 mg/kg) of bupropion. The patient was admitted to pediatric intensive care unit (PICU) where toxicity was resolved promptly following administration of intravenous lipid emulsion (ILE) infusion. ILE is a first-line treatment for other forms of toxicity including unintended local anesthetic administration. ILE use is not a first-line treatment in this setting, but this case presents a positive subsequent patient outcome.
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