Generation of Indoles with Agrochemical Significance through Biotransformation by <i>Chaetomium globosum</i>

Abstract

Six new (<b>1</b>-<b>6</b>) and two known (<b>7</b> and <b>8</b>) indole alkaloids were produced by the marine fish-derived fungus <i>Chaetomium globosum</i> 1C51 through biotransformation. The structures of these alkaloids were elucidated by a combination of MS, NMR, and X-ray crystallography analyses. Chaetoindolone A (<b>1</b>) was shown to inhibit the growth of the rice-pathogenic bacteria <i>Xanthomonas oryzae</i> pv. <i>oryzae</i> (<i>xoo</i>) both in vitro and in vivo. Chaetogline A (<b>7</b>) was found to be fungicidal against <i>Sclerotinia sclerotiorum</i>, a pathogen causing rape sclerotinia rot. Collectively, this work provides access to new indole alkaloids with potential agrochemical significance.