Antimicrobial Agents and Chemotherapy · 2019 · 16 citations · 13 references
MedicineMicrobiologyOphthalmologyAntimicrobial PharmacotherapyAntimicrobial ResistanceOcular MicrobiologyAntibiotic ResistanceBacterial Eye InfectionsCorneal InfectionMicrobial KeratitisOcular Antimicrobial TherapyTopical Ophthalmic MedicationsAntibiotic Ophthalmic TherapyBacterial Keratitis TreatmentInfectious KeratopathyIntraocular Antibiotic TherapyMurine ModelsPseudomonas Aeruginosa Infection TreatmentPseudomonas Aeruginosa KeratitisTopical Antibacterial Therapy
Bacterial keratitis causes significant blindness, yet antimicrobial resistance has rendered current treatments ineffective. Polymyxin B-trimethoprim (PT) plus rifampin has potent in vitro activity against Staphylococcus aureus and Pseudomonas aeruginosa , two important causes of keratitis. Here we further characterize this combination against P. aeruginosa in a murine keratitis model.
13
Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase
Elizabeth A. Campbell, Nataliya Korzheva, Arkady Mustaev et al. · Cell · 2001 · 1.5K citations · Full text
Corneal blindness: a global perspective.
John P. Whitcher, Muthiah Srinivasan, Madan Prasad Upadhyay · PubMed · 2001 · 1.5K citations
Richard A. Gleckman, Noel Blagg, Dennis W. Joubert · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · 1981 · 164 citations
Antibiotic Resistance Among Ocular Pathogens in the United States
Penny A. Asbell, Christine M. Sanfilippo, Christopher M. Pillar et al. · JAMA Ophthalmology · 2015 · 156 citations