Synergy Testing of Antiamoebic Agents for Acanthamoeba: Antagonistic Effect of Voriconazole

Abstract

In an in vitro assay, voriconazole reduced the cysticidal activity of 2 commonly used antiamoebic drugs. Although the in vivo drug interactions could be different, these observations may be useful in cases of nonhealing Acanthamoeba keratitis being treated with combination therapies that include voriconazole.