PTBP3 contributes to colorectal cancer growth and metastasis via translational activation of HIF-1α

Abstract

PTBP3 appears to be a novel oncogene of CRC through binding to the IRES region of HIF-1α mRNA, which regulates HIF-1α translation. PTBP3 can serve as a promising predictive biomarker for recurrence and prognosis in patients with CRC.