Fully-automated radiosynthesis of the amyloid tracer [11C] PiB via direct [11C]CO2 fixation-reduction

Abstract

The viability of the system PhSiH₃ / TBAF to efficiently promote the radiosynthesis of [¹¹C] PiB via direct [¹¹C]CO₂ fixation-reduction has been demonstrated. [¹¹C] PiB was obtained through a fully automated radiosynthesis with a satisfactory yield, purity and molar activity. According to the results, the one-pot methodology employed could reliably yield sufficiently high tracer amounts for preclinical and clinical use.